Assay Detail
Binding
CHEMBL983765
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Inhibition of Toxoplasma gondii dihydrofolate reductase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.49 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.96 |
| CHEMBL515312 | — | — | 1 | 7.24 |
| CHEMBL478403 | — | — | 1 | 7.19 |
| CHEMBL104787 | — | — | 1 | 7.16 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.10 |
| CHEMBL516891 | — | — | 1 | 6.92 |
| CHEMBL476945 | — | — | 1 | 6.92 |
| CHEMBL478213 | — | — | 1 | 6.82 |
| CHEMBL477790 | — | — | 1 | 6.64 |
| CHEMBL478192 | — | — | 1 | 6.52 |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 6.34 |
| CHEMBL478191 | — | — | 1 | 6.28 |
| CHEMBL478404 | — | — | 1 | 6.22 |
| CHEMBL476745 | — | — | 1 | 6.00 |
| CHEMBL477151 | — | — | 1 | 5.85 |
| CHEMBL516128 | — | — | 1 | 5.85 |
| CHEMBL476744 | — | — | 1 | 5.85 |
| CHEMBL477150 | — | — | 1 | 5.82 |
| CHEMBL477566 | — | — | 1 | 5.57 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.54 |
| CHEMBL477789 | — | — | 1 | - |
| CHEMBL514219 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL515312 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL478403 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL104787 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL516891 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL476945 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL478213 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL477790 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL478192 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL225072 | PEMETREXED | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL478191 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL478404 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL476745 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL477151 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL516128 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL476744 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL477150 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL477566 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL477789 | — | IC50 | - | — | - | |
| CHEMBL514219 | — | IC50 | - | — | - |