Assay Detail
Binding
CHEMBL983954
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Inhibition of human recombinant IKK2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.01 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520473 | — | — | 1 | 7.80 |
| CHEMBL483165 | — | — | 1 | 7.70 |
| CHEMBL519965 | — | — | 1 | 7.70 |
| CHEMBL482747 | — | — | 1 | 7.70 |
| CHEMBL483557 | — | — | 1 | 7.70 |
| CHEMBL482539 | — | — | 1 | 7.50 |
| CHEMBL473080 | — | — | 1 | 7.40 |
| CHEMBL483166 | — | — | 1 | 7.40 |
| CHEMBL482540 | — | — | 1 | 7.40 |
| CHEMBL520308 | — | — | 1 | 7.40 |
| CHEMBL485145 | — | — | 1 | 7.20 |
| CHEMBL482746 | — | — | 1 | 7.10 |
| CHEMBL453707 | — | — | 1 | 6.80 |
| CHEMBL520954 | — | — | 1 | 6.70 |
| CHEMBL520655 | — | — | 1 | 6.60 |
| CHEMBL484966 | — | — | 1 | 6.50 |
| CHEMBL519028 | — | — | 1 | 6.50 |
| CHEMBL504261 | — | — | 1 | 6.20 |
| CHEMBL482538 | — | — | 1 | 5.50 |
| CHEMBL482553 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520473 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL483165 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL519965 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL482747 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL483557 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL482539 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL473080 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL483166 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL482540 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL520308 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL485145 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL482746 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL453707 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL520954 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL520655 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL484966 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL519028 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL504261 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL482538 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL482553 | — | IC50 | = | 5011.87 | nM | 5.30 |