Assay Detail
Functional
CHEMBL983957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha-induced NF-kappaB receptor activation in human A549 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.15 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483165 | — | — | 1 | 7.30 |
| CHEMBL482747 | — | — | 1 | 6.50 |
| CHEMBL483557 | — | — | 1 | 6.30 |
| CHEMBL483166 | — | — | 1 | 6.30 |
| CHEMBL473080 | — | — | 1 | 6.20 |
| CHEMBL520308 | — | — | 1 | 6.10 |
| CHEMBL485145 | — | — | 1 | 6.00 |
| CHEMBL520473 | — | — | 1 | 5.70 |
| CHEMBL484966 | — | — | 1 | 5.70 |
| CHEMBL519965 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483165 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL482747 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL483557 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL483166 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL473080 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL520308 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL485145 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL520473 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL484966 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL519965 | — | IC50 | = | 3981.07 | nM | 5.40 |