Assay Detail
Binding
CHEMBL984055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase p66/p51
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.00 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466773 | SOULATTROLIDE | — | 1 | 6.14 |
| CHEMBL7187 | COSTATOLIDE | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466773 | SOULATTROLIDE | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL7187 | COSTATOLIDE | IC50 | = | 1400.0 | nM | 5.85 |