Assay Detail

CHEMBL984178

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of FGFR

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.

Cirillo PF, Hickey ER, Moss N, Breitfelder S, Betageri R, Fadra T, Gaenzler F, Gilmore T, Goldberg DR, Kamhi V, Kirrane T, Kroe RR, Madwed J, Moriak M, Netherton M, Pargellis CA, Patel UR, Qian KC, Sharma R, Sun S, Swinamer A, Torcellini C, Takahashi H, Tsang M, Xiong Z.
Bioorg Med Chem Lett (2009) 19 : 2386 -2391
PubMed 19356929 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.11	5.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL451523	—	—	1	5.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL451523	—	IC50	=	7700.0	nM	5.11