Assay Detail
Functional
CHEMBL984240
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Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.63 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473567 | — | — | 1 | 5.72 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 4.94 |
| CHEMBL482359 | — | — | 1 | 4.79 |
| CHEMBL482200 | — | — | 1 | 4.41 |
| CHEMBL506313 | — | — | 1 | 4.23 |
| CHEMBL467525 | — | — | 1 | 4.21 |
| CHEMBL509581 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473567 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL844 | BRIMONIDINE | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL482359 | — | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL482200 | — | EC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL506313 | — | EC50 | = | 59300.0 | nM | 4.23 |
| CHEMBL467525 | — | EC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL509581 | — | EC50 | = | 82300.0 | nM | 4.08 |