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Assay Detail

CHEMBL984427

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Functional
Antiviral activity against CVB2 infected in Vero76 cells assessed as reduction in virus plaque formation after 4 days by MTT assay
ChEMBL ↗
85
Total Activities
85
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Coxsackievirus B2
Cell Type Vero 76
Confidence 1 — Organism
Curated By Autocuration

Target

Coxsackievirus B2 (CHEMBL613202) ↗
Type ORGANISM
Organism Coxsackievirus B2

Publication

Antimicrobial and cytotoxic arylazoenamines. Part III: antiviral activity of selected classes of arylazoenamines.
Tonelli M, Boido V, Canu C, Sparatore A, Sparatore F, Paneni MS, Fermeglia M, Pricl S, La Colla P, Casula L, Ibba C, Collu D, Loddo R.
Bioorg Med Chem (2008) 16 : 8447 -8465
PubMed 18760610 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 85 4.74 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL490998 — — 1 6.05
CHEMBL476984 — — 1 5.40
CHEMBL475475 — — 1 5.40
CHEMBL504564 — — 1 5.40
CHEMBL489373 — — 1 5.30
CHEMBL490999 — — 1 5.30
CHEMBL489564 — — 1 5.30
CHEMBL451317 — — 1 5.30
CHEMBL476974 — — 1 5.30
CHEMBL442892 — — 1 5.30
CHEMBL498976 — — 1 5.22
CHEMBL523441 — — 1 5.22
CHEMBL490997 — — 1 5.22
CHEMBL490784 — — 1 5.16
CHEMBL491006 — — 1 5.16
CHEMBL501654 — — 1 5.16
CHEMBL476784 — — 1 5.10
CHEMBL478860 — — 1 5.05
CHEMBL489169 — — 1 5.00
CHEMBL510108 — — 1 5.00
CHEMBL446919 — — 1 4.92
CHEMBL491207 — — 1 4.85
CHEMBL470987 — — 1 4.85
CHEMBL476147 — — 1 4.80
CHEMBL517807 — — 1 4.80
CHEMBL450720 — — 1 4.75
CHEMBL477187 — — 1 4.72
CHEMBL490061 — — 1 4.72
CHEMBL418899 2'-B-METHYL-GUANOSINE — 1 4.70
CHEMBL489779 — — 1 4.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL490998 — EC50 = 900.0 nM 6.05
CHEMBL476984 — EC50 = 4000.0 nM 5.40
CHEMBL504564 — EC50 = 4000.0 nM 5.40
CHEMBL475475 — EC50 = 4000.0 nM 5.40
CHEMBL489373 — EC50 = 5000.0 nM 5.30
CHEMBL490999 — EC50 = 5000.0 nM 5.30
CHEMBL489564 — EC50 = 5000.0 nM 5.30
CHEMBL451317 — EC50 = 5000.0 nM 5.30
CHEMBL476974 — EC50 = 5000.0 nM 5.30
CHEMBL442892 — EC50 = 5000.0 nM 5.30
CHEMBL498976 — EC50 = 6000.0 nM 5.22
CHEMBL523441 — EC50 = 6000.0 nM 5.22
CHEMBL490997 — EC50 = 6000.0 nM 5.22
CHEMBL491006 — EC50 = 7000.0 nM 5.16
CHEMBL490784 — EC50 = 7000.0 nM 5.16
CHEMBL501654 — EC50 = 7000.0 nM 5.16
CHEMBL476784 — EC50 = 8000.0 nM 5.10
CHEMBL478860 — EC50 = 9000.0 nM 5.05
CHEMBL489169 — EC50 = 10000.0 nM 5.00
CHEMBL510108 — EC50 = 10000.0 nM 5.00
CHEMBL446919 — EC50 = 12000.0 nM 4.92
CHEMBL491207 — EC50 = 14000.0 nM 4.85
CHEMBL470987 — EC50 = 14000.0 nM 4.85
CHEMBL476147 — EC50 = 16000.0 nM 4.80
CHEMBL517807 — EC50 = 16000.0 nM 4.80
CHEMBL450720 — EC50 = 18000.0 nM 4.75
CHEMBL490061 — EC50 = 19000.0 nM 4.72
CHEMBL477187 — EC50 = 19000.0 nM 4.72
CHEMBL418899 2'-B-METHYL-GUANOSINE EC50 = 20000.0 nM 4.70
CHEMBL489779 — EC50 = 21000.0 nM 4.68
CHEMBL445306 — EC50 = 22000.0 nM 4.66
CHEMBL476783 — EC50 = 23000.0 nM 4.64
CHEMBL470505 — EC50 = 24000.0 nM 4.62
CHEMBL505701 — EC50 = 26000.0 nM 4.58
CHEMBL502222 — EC50 = 27000.0 nM 4.57
CHEMBL477176 — EC50 = 27000.0 nM 4.57
CHEMBL515944 — EC50 = 30000.0 nM 4.52
CHEMBL478859 — EC50 = 30000.0 nM 4.52
CHEMBL490761 — EC50 = 32000.0 nM 4.50
CHEMBL476973 — EC50 = 34000.0 nM 4.47
CHEMBL477606 — EC50 = 34000.0 nM 4.47
CHEMBL442570 — EC50 = 35000.0 nM 4.46
CHEMBL477550 — EC50 = 35000.0 nM 4.46
CHEMBL476148 — EC50 = 36000.0 nM 4.44
CHEMBL448446 — EC50 = 38000.0 nM 4.42
CHEMBL508059 — EC50 = 40000.0 nM 4.40
CHEMBL489776 — EC50 = 41000.0 nM 4.39
CHEMBL448063 — EC50 = 42000.0 nM 4.38
CHEMBL518440 — EC50 = 44000.0 nM 4.36
CHEMBL489777 — EC50 = 45000.0 nM 4.35