Assay Detail
Functional
CHEMBL984536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNFalpha production in Squirrel monkey whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Saimiri sciureus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.92 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485620 | — | — | 1 | 8.15 |
| CHEMBL372575 | — | — | 1 | 7.96 |
| CHEMBL485629 | MK-0873 | 2.0 | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485620 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL372575 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL485629 | MK-0873 | IC50 | = | 23.0 | nM | 7.64 |