Assay Detail
Binding
CHEMBL984565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cataracted human eye lens aldose reductase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.83 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 7.83 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | - |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
| CHEMBL1414 | SYRINGIC ACID | — | 1 | - |
| CHEMBL66879 | COUMARIC ACID | — | 1 | - |
| CHEMBL37537 | PROTOCATECHUIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL288114 | GALLIC ACID | IC50 | = | 97.3 | ug.mL-1 | - |
| CHEMBL27246 | CINNAMIC ACID | IC50 | = | 68.1 | ug.mL-1 | - |
| CHEMBL1414 | SYRINGIC ACID | IC50 | = | 172.1 | ug.mL-1 | - |
| CHEMBL66879 | COUMARIC ACID | IC50 | = | 162.31 | ug.mL-1 | - |
| CHEMBL37537 | PROTOCATECHUIC ACID | IC50 | = | 42.7 | ug.mL-1 | - |