Assay Detail
Binding
CHEMBL984569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of estradiol-induced coactivator peptide SRC1 binding to estrogen receptor alpha expressed in human HEC1 cells after 24 hrs by luciferase based mammalian two-hybrid assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEC-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Envelope glycoprotein gp70 (CHEMBL5825) ↗| Type | SINGLE PROTEIN |
| Organism | Mouse mammary tumor virus (strain GR) (MMTV) |
Publication
Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.31 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456106 | — | — | 1 | 5.68 |
| CHEMBL456392 | — | — | 1 | 5.60 |
| CHEMBL460174 | — | — | 1 | 5.58 |
| CHEMBL448651 | — | — | 1 | 5.44 |
| CHEMBL456179 | — | — | 1 | 5.42 |
| CHEMBL456594 | — | — | 1 | 5.40 |
| CHEMBL458496 | — | — | 1 | 5.34 |
| CHEMBL456599 | — | — | 1 | 5.31 |
| CHEMBL512206 | — | — | 1 | 5.23 |
| CHEMBL456598 | — | — | 1 | 5.17 |
| CHEMBL456393 | — | — | 1 | 5.03 |
| CHEMBL285853 | — | — | 1 | 4.95 |
| CHEMBL33663 | — | — | 1 | 4.94 |
| CHEMBL456600 | — | — | 1 | - |
| CHEMBL458495 | — | — | 1 | - |
| CHEMBL459968 | — | — | 1 | - |
| CHEMBL508968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456106 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL456392 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL460174 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL448651 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL456179 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL456594 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL458496 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL456599 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL512206 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL456598 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL456393 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL285853 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL33663 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL456600 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL458495 | — | IC50 | - | — | - | |
| CHEMBL459968 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL508968 | — | IC50 | - | — | - |