Assay Detail
Binding
CHEMBL984593
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Displacement of [3H]1-alpha,25-(OH)2D3 from rat recombinant full length VDR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.33 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.30 |
| CHEMBL263638 | — | — | 1 | 9.00 |
| CHEMBL261197 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL263638 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL261197 | — | Ki | = | 2.0 | nM | 8.70 |