Assay Detail
Binding
CHEMBL984664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.10 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 7.33 |
| CHEMBL1383 | DDA-TRIPHOSPHATE | -1.0 | 1 | 7.30 |
| CHEMBL1162283 | — | — | 1 | 6.96 |
| CHEMBL1162284 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL1383 | DDA-TRIPHOSPHATE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1162283 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1162284 | — | Ki | = | 150.0 | nM | 6.82 |