Assay Detail
Binding
CHEMBL984852
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Inhibition of ubiquinone binding site of human dihydroorotate dehydrogenase
34
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.41 | 8.57 |
| IC50 | 17 | 6.50 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484780 | — | — | 2 | 8.57 |
| CHEMBL142996 | — | — | 2 | 8.15 |
| CHEMBL519160 | — | — | 2 | 7.96 |
| CHEMBL141732 | — | — | 2 | 7.85 |
| CHEMBL483995 | — | — | 2 | 7.80 |
| CHEMBL484531 | — | — | 2 | 7.80 |
| CHEMBL520306 | — | — | 2 | 7.68 |
| CHEMBL483552 | — | — | 2 | 7.66 |
| CHEMBL520008 | — | — | 2 | 7.64 |
| CHEMBL505315 | — | — | 2 | 7.60 |
| CHEMBL483161 | — | — | 2 | 7.60 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 2 | 7.50 |
| CHEMBL483994 | — | — | 2 | 7.41 |
| CHEMBL520999 | — | — | 2 | 7.40 |
| CHEMBL484595 | — | — | 2 | 6.72 |
| CHEMBL484594 | — | — | 2 | 5.70 |
| CHEMBL484602 | — | — | 2 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484780 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL142996 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL519160 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL141732 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL483995 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL484531 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL520306 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL484780 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL483552 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL520008 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL505315 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL483161 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL973 | TERIFLUNOMIDE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL483994 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL520999 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL142996 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL519160 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL141732 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL483995 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL484531 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL520306 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL483552 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL484595 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL520008 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL505315 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL483161 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL483994 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL520999 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL484595 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL484594 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL484602 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL484594 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL484602 | — | IC50 | = | 86600.0 | nM | 4.06 |