Assay Detail

CHEMBL985141

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Binding

Inhibition of Escherichia coli CTX-M-15

ChEMBL ↗

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Target

Beta-lactamase CTX-M (CHEMBL6131) ↗

Open DB target context

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Beta-lactamase CTX-M (CHEMBL6131) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-lactamase CTX-M

CHEMBL6131

Anchored from Assay target.

Protein identity Beta-lactamase CTX-M

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Beta-lactamase CTX-M (CHEMBL6131) ↗

Type	SINGLE PROTEIN
Organism	Escherichia coli

Publication

Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.

Queenan AM, Shang W, Kania M, Page MG, Bush K.
Antimicrob Agents Chemother (2007) 51 : 3089 -3095
PubMed 17591851 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.38	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL404	TAZOBACTAM	4.0	1	8.70
CHEMBL777	CLAVULANIC ACID	4.0	1	8.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL404	TAZOBACTAM	IC50	=	2.0	nM	8.70
CHEMBL777	CLAVULANIC ACID	IC50	=	9.0	nM	8.05