Assay Detail
Binding
CHEMBL985261
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Inhibition of PLK1
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.09 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 9.10 |
| CHEMBL477407 | — | — | 1 | 7.64 |
| CHEMBL477408 | — | — | 1 | 7.47 |
| CHEMBL477615 | — | — | 1 | 7.44 |
| CHEMBL477616 | — | — | 1 | 7.43 |
| CHEMBL475881 | — | — | 1 | 7.39 |
| CHEMBL503480 | — | — | 1 | 7.34 |
| CHEMBL514371 | — | — | 1 | 7.15 |
| CHEMBL515457 | — | — | 1 | 7.13 |
| CHEMBL476575 | — | — | 1 | 7.09 |
| CHEMBL476136 | — | — | 1 | 7.00 |
| CHEMBL476137 | — | — | 1 | 6.80 |
| CHEMBL476782 | — | — | 1 | 6.72 |
| CHEMBL476138 | — | — | 1 | 6.57 |
| CHEMBL478654 | — | — | 1 | 6.48 |
| CHEMBL475946 | — | — | 1 | 6.46 |
| CHEMBL475947 | — | — | 1 | 6.31 |
| CHEMBL516582 | — | — | 1 | 6.30 |
| CHEMBL516110 | — | — | 1 | 6.28 |
| CHEMBL477393 | — | — | 1 | 6.26 |
| CHEMBL477604 | — | — | 1 | 6.24 |
| CHEMBL477605 | — | — | 1 | 6.12 |
| CHEMBL476145 | — | — | 1 | 6.02 |
| CHEMBL476146 | — | — | 1 | 5.98 |
| CHEMBL478892 | — | — | 1 | 5.80 |
| CHEMBL476123 | — | — | 1 | 5.80 |
| CHEMBL507146 | — | — | 1 | 5.70 |
| CHEMBL476124 | CYCLAPOLIN 9 | — | 1 | 5.62 |
| CHEMBL442957 | — | — | 1 | 5.30 |
| CHEMBL518265 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513909 | BI-2536 | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL477407 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL477408 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL477615 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL477616 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL475881 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL503480 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL514371 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL515457 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL476575 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL476136 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL476137 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL476782 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL476138 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL478654 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL475946 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL475947 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL516582 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL516110 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL477393 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL477604 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL477605 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL476145 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL476146 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL478892 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL476123 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL507146 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL476124 | CYCLAPOLIN 9 | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL442957 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL518265 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL455343 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL476125 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL504667 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL492008 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL47590 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL516429 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL28626 | MORIN | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL526709 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL450653 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL492009 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL523487 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL50 | QUERCETIN | IC50 | = | 64000.0 | nM | 4.19 |