Assay Detail
Binding
CHEMBL985385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescein labeled BAD peptide from Bcl-XL by fluorescence polarization assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Bcl2-associated agonist of cell death (CHEMBL3817) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.35 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448740 | — | — | 1 | 8.85 |
| CHEMBL508864 | — | — | 1 | 7.85 |
| CHEMBL508865 | — | — | 1 | - |
| CHEMBL452892 | — | — | 1 | - |
| CHEMBL473870 | — | — | 1 | - |
| CHEMBL451683 | — | — | 1 | - |
| CHEMBL466090 | — | — | 1 | - |
| CHEMBL469778 | — | — | 1 | - |
| CHEMBL501889 | — | — | 1 | - |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | - |
| CHEMBL510761 | — | — | 1 | - |
| CHEMBL444481 | — | — | 1 | - |
| CHEMBL449676 | — | — | 1 | - |
| CHEMBL509460 | — | — | 1 | - |
| CHEMBL508093 | — | — | 1 | - |
| CHEMBL500815 | — | — | 1 | - |
| CHEMBL510351 | — | — | 1 | - |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | - |
| CHEMBL508210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448740 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL508864 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL508865 | — | Ki | < | 1.0 | nM | - |
| CHEMBL452892 | — | Ki | < | 1.0 | nM | - |
| CHEMBL473870 | — | Ki | < | 1.0 | nM | - |
| CHEMBL451683 | — | Ki | < | 1.0 | nM | - |
| CHEMBL466090 | — | Ki | < | 1.0 | nM | - |
| CHEMBL469778 | — | Ki | < | 1.0 | nM | - |
| CHEMBL501889 | — | Ki | < | 1.0 | nM | - |
| CHEMBL376408 | ABT 737 | Ki | < | 1.0 | nM | - |
| CHEMBL510761 | — | Ki | < | 1.0 | nM | - |
| CHEMBL444481 | — | Ki | < | 1.0 | nM | - |
| CHEMBL449676 | — | Ki | < | 1.0 | nM | - |
| CHEMBL509460 | — | Ki | < | 1.0 | nM | - |
| CHEMBL508093 | — | Ki | < | 1.0 | nM | - |
| CHEMBL500815 | — | Ki | < | 1.0 | nM | - |
| CHEMBL510351 | — | Ki | < | 1.0 | nM | - |
| CHEMBL443684 | NAVITOCLAX | Ki | < | 1.0 | nM | - |
| CHEMBL508210 | — | Ki | < | 1.0 | nM | - |