Assay Detail
Binding
CHEMBL985439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DPP4 in human plasma by fluorescence assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 8.09 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1744354 | — | — | 1 | 8.96 |
| CHEMBL487860 | — | — | 1 | 8.82 |
| CHEMBL521224 | — | — | 1 | 8.62 |
| CHEMBL470477 | — | — | 1 | 8.59 |
| CHEMBL500008 | — | — | 1 | 8.57 |
| CHEMBL487680 | — | — | 1 | 8.55 |
| CHEMBL488036 | — | — | 1 | 8.54 |
| CHEMBL512726 | — | — | 1 | 8.54 |
| CHEMBL451937 | — | — | 1 | 8.51 |
| CHEMBL470476 | — | — | 1 | 8.51 |
| CHEMBL469659 | — | — | 1 | 8.51 |
| CHEMBL470681 | — | — | 1 | 8.48 |
| CHEMBL513725 | — | — | 1 | 8.48 |
| CHEMBL511785 | — | — | 1 | 8.39 |
| CHEMBL488418 | — | — | 1 | 8.35 |
| CHEMBL472096 | — | — | 1 | 8.34 |
| CHEMBL469660 | — | — | 1 | 8.28 |
| CHEMBL488419 | — | — | 1 | 8.27 |
| CHEMBL519585 | — | — | 1 | 8.24 |
| CHEMBL487861 | — | — | 1 | 8.24 |
| CHEMBL471088 | — | — | 1 | 8.21 |
| CHEMBL77538 | — | — | 1 | 8.15 |
| CHEMBL470893 | — | — | 1 | 8.14 |
| CHEMBL472102 | — | — | 1 | 8.11 |
| CHEMBL487681 | — | — | 1 | 8.09 |
| CHEMBL454193 | — | — | 1 | 8.08 |
| CHEMBL471089 | — | — | 1 | 8.07 |
| CHEMBL469452 | — | — | 1 | 8.06 |
| CHEMBL512890 | — | — | 1 | 7.92 |
| CHEMBL1203962 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1744354 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL487860 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL521224 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL470477 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL500008 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL487680 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL488036 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL512726 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL451937 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL470476 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL469659 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL513725 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL470681 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL511785 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL488418 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL472096 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL469660 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL488419 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL519585 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL487861 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL471088 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL77538 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL470893 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL472102 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL487681 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL454193 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL471089 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL469452 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL512890 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1203962 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL487862 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL508845 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL512694 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL472101 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL520854 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL470330 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL485828 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL485827 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL472100 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL488810 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL511128 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL504237 | — | IC50 | > | 316.0 | nM | - |
| CHEMBL472097 | — | IC50 | > | 316.0 | nM | - |