Assay Detail
Binding
CHEMBL985545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]NA uptake at human NET expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.95 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245880 | — | — | 1 | 8.30 |
| CHEMBL245687 | — | — | 1 | 7.92 |
| CHEMBL476954 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245880 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL245687 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL476954 | — | IC50 | = | 23.0 | nM | 7.64 |