Assay Detail
ADMET
CHEMBL985547
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Metabolic stability in human liver microsomes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 2 — Organism |
| Curated By | Autocuration |
Publication
Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245880 | — | — | 1 | 7.00 |
| CHEMBL476954 | — | — | 1 | - |
| CHEMBL245687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245880 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL476954 | — | IC50 | > | 120.0 | nM | - |
| CHEMBL245687 | — | IC50 | > | 120.0 | nM | - |