Assay Detail
Binding
CHEMBL985694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2 in human whole blood assessed as effect on thrombin-induced TXB2 production
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.04 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.18 |
| CHEMBL517675 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL865 | VALDECOXIB | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL517675 | — | IC50 | = | 1300.0 | nM | 5.89 |