Assay Detail
Functional
CHEMBL985756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.81 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 10.10 |
| CHEMBL451711 | — | — | 1 | 9.60 |
| CHEMBL185151 | HEMIASTERLIN | — | 1 | 9.52 |
| CHEMBL514729 | HEMIASTERLIN METHYL ESTER | — | 1 | 9.30 |
| CHEMBL459013 | — | — | 1 | 9.10 |
| CHEMBL459188 | — | — | 1 | 9.10 |
| CHEMBL457755 | HEMIASTERLINS A | — | 1 | 8.70 |
| CHEMBL452491 | — | — | 1 | 8.52 |
| CHEMBL511040 | — | — | 1 | 8.40 |
| CHEMBL362764 | — | — | 1 | 8.22 |
| CHEMBL185704 | — | — | 1 | 8.15 |
| CHEMBL457935 | HEMIASTERLINS B | — | 1 | 8.15 |
| CHEMBL189034 | — | — | 1 | 7.82 |
| CHEMBL454574 | — | — | 1 | 7.60 |
| CHEMBL508523 | — | — | 1 | 7.52 |
| CHEMBL452490 | — | — | 1 | 7.40 |
| CHEMBL458123 | — | — | 1 | 7.40 |
| CHEMBL462824 | — | — | 1 | 7.30 |
| CHEMBL516318 | — | — | 1 | 7.22 |
| CHEMBL453287 | — | — | 1 | 6.82 |
| CHEMBL517313 | — | — | 1 | 6.52 |
| CHEMBL444425 | CRIAMIDES A | — | 1 | 6.00 |
| CHEMBL454573 | — | — | 1 | 5.80 |
| CHEMBL517765 | — | — | 1 | 5.60 |
| CHEMBL188891 | — | — | 1 | 5.40 |
| CHEMBL455093 | — | — | 1 | - |
| CHEMBL541670 | — | — | 1 | - |
| CHEMBL463610 | — | — | 1 | - |
| CHEMBL463416 | — | — | 1 | - |
| CHEMBL457939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL451711 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL185151 | HEMIASTERLIN | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL514729 | HEMIASTERLIN METHYL ESTER | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL459013 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL459188 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL457755 | HEMIASTERLINS A | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL452491 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL511040 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL362764 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL185704 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL457935 | HEMIASTERLINS B | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL189034 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL454574 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL508523 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL452490 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL458123 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL462824 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL516318 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL453287 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL517313 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL444425 | CRIAMIDES A | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL454573 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL517765 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL188891 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL455093 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL541670 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL463610 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL463416 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL457939 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL456855 | — | IC50 | - | — | - |