Assay Detail
Binding
CHEMBL985926
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Inhibition of potato LOX5
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Solanum tuberosum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.46 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482206 | — | — | 1 | 5.50 |
| CHEMBL481613 | — | — | 1 | 5.48 |
| CHEMBL521440 | — | — | 1 | 5.47 |
| CHEMBL447148 | — | — | 1 | 5.46 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482206 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL481613 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL521440 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL447148 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 4000.0 | nM | 5.40 |