Assay Detail
Binding
CHEMBL986117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Electrophorus electricus AChE by Ellman's method
23
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.26 | 6.70 |
| Ki | 4 | 6.42 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458398 | — | — | 2 | 6.89 |
| CHEMBL499285 | — | — | 2 | 6.70 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 2 | 6.35 |
| CHEMBL461515 | — | — | 2 | 6.35 |
| CHEMBL461514 | — | — | 1 | 5.82 |
| CHEMBL452742 | — | — | 1 | 5.51 |
| CHEMBL457684 | — | — | 1 | 5.32 |
| CHEMBL442866 | — | — | 1 | 5.15 |
| CHEMBL465728 | — | — | 1 | 5.04 |
| CHEMBL500712 | — | — | 1 | 4.90 |
| CHEMBL450898 | — | — | 1 | 4.85 |
| CHEMBL463856 | — | — | 1 | 4.82 |
| CHEMBL517342 | — | — | 1 | 4.67 |
| CHEMBL458578 | — | — | 1 | 4.64 |
| CHEMBL445976 | — | — | 1 | 4.46 |
| CHEMBL465710 | — | — | 1 | 4.34 |
| CHEMBL503053 | — | — | 1 | 4.33 |
| CHEMBL465727 | — | — | 1 | - |
| CHEMBL513440 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458398 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL499285 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL461515 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL458398 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL499285 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL461515 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL461514 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL452742 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL457684 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL442866 | — | IC50 | = | 7070.0 | nM | 5.15 |
| CHEMBL465728 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL500712 | — | IC50 | = | 12550.0 | nM | 4.90 |
| CHEMBL450898 | — | IC50 | = | 14040.0 | nM | 4.85 |
| CHEMBL463856 | — | IC50 | = | 15090.0 | nM | 4.82 |
| CHEMBL517342 | — | IC50 | = | 21470.0 | nM | 4.67 |
| CHEMBL458578 | — | IC50 | = | 22890.0 | nM | 4.64 |
| CHEMBL445976 | — | IC50 | = | 34960.0 | nM | 4.46 |
| CHEMBL465710 | — | IC50 | = | 45420.0 | nM | 4.34 |
| CHEMBL503053 | — | IC50 | = | 46430.0 | nM | 4.33 |
| CHEMBL465727 | — | IC50 | = | 142580.0 | nM | - |
| CHEMBL513440 | — | IC50 | = | 120700.0 | nM | - |