Assay Detail
Binding
CHEMBL986178
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Inhibition of Kca channel
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.84 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525408 | APAMIN | — | 1 | 10.52 |
| CHEMBL117908 | — | — | 1 | 8.52 |
| CHEMBL510780 | — | — | 1 | 6.30 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525408 | APAMIN | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL117908 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL510780 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | IC50 | = | 1000.0 | nM | 6.00 |