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Assay Detail

CHEMBL986294

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AchE by Ellman's method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Carolan CG, Dillon GP, Gaynor JM, Reidy S, Ryder SA, Khan D, Marquez JF, Gilmer JF.
J Med Chem (2008) 51 : 6400 -6409
PubMed 18817366 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.03 7.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL464538 1 7.20
CHEMBL94 PHYSOSTIGMINE 3.0 1 6.99
CHEMBL494887 TETRAISOPROPYL PYROPHOSPHORAMIDE 1 5.60
CHEMBL493458 1 5.00
CHEMBL492179 1 4.76
CHEMBL492482 1 4.42
CHEMBL492898 1 4.36
CHEMBL523005 1 4.29
CHEMBL492635 1 4.25
CHEMBL492233 1 4.25
CHEMBL521810 1 4.22
CHEMBL494520 1 -
CHEMBL494519 1 -
CHEMBL523830 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL464538 IC50 = 63.0 nM 7.20
CHEMBL94 PHYSOSTIGMINE IC50 = 103.0 nM 6.99
CHEMBL494887 TETRAISOPROPYL PYROPHOSPHORAMIDE IC50 = 2500.0 nM 5.60
CHEMBL493458 IC50 = 9900.0 nM 5.00
CHEMBL492179 IC50 = 17200.0 nM 4.76
CHEMBL492482 IC50 = 37600.0 nM 4.42
CHEMBL492898 IC50 = 43400.0 nM 4.36
CHEMBL523005 IC50 = 51600.0 nM 4.29
CHEMBL492635 IC50 = 56300.0 nM 4.25
CHEMBL492233 IC50 = 55900.0 nM 4.25
CHEMBL521810 IC50 = 60400.0 nM 4.22
CHEMBL494520 IC50 = 1440000.0 nM -
CHEMBL494519 IC50 = 1520000.0 nM -
CHEMBL523830 IC50 = 272500.0 nM -