Assay Detail
Binding
CHEMBL986499
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Inhibition of c-Src by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.09 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478611 | EPIHEMATOXYLOL | — | 1 | 6.44 |
| CHEMBL477197 | HEMATOXYLIN | — | 1 | 6.36 |
| CHEMBL477560 | HEMATOXYLENE | — | 1 | 5.80 |
| CHEMBL477768 | HEMATOXYLONE | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478611 | EPIHEMATOXYLOL | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL477197 | HEMATOXYLIN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL477560 | HEMATOXYLENE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL477768 | HEMATOXYLONE | IC50 | = | 1800.0 | nM | 5.75 |