Assay Detail
Binding
CHEMBL986503
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Inhibition of KDR by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.41 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477197 | HEMATOXYLIN | — | 1 | 5.68 |
| CHEMBL478611 | EPIHEMATOXYLOL | — | 1 | 5.68 |
| CHEMBL477768 | HEMATOXYLONE | — | 1 | 5.21 |
| CHEMBL477560 | HEMATOXYLENE | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477197 | HEMATOXYLIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL478611 | EPIHEMATOXYLOL | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL477768 | HEMATOXYLONE | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL477560 | HEMATOXYLENE | IC50 | = | 8600.0 | nM | 5.07 |