Assay Detail
Functional
CHEMBL986574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells by TRE-luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor beta (TR-beta) selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.54 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41036 | — | — | 1 | 8.95 |
| CHEMBL480312 | — | — | 1 | 7.16 |
| CHEMBL480313 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41036 | — | EC50 | = | 1.12 | nM | 8.95 |
| CHEMBL480312 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL480313 | — | EC50 | = | 317.0 | nM | 6.50 |