Assay Detail
Binding
CHEMBL986635
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Inhibition of His-tagged human platelet 12-lipoxygenase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.81 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.75 |
| CHEMBL463805 | — | — | 1 | 6.58 |
| CHEMBL459185 | — | — | 1 | 6.55 |
| CHEMBL463806 | — | — | 1 | 6.11 |
| CHEMBL465616 | CHLOROPUUPEHENONE | — | 1 | 5.62 |
| CHEMBL157844 | PUUPEHENONE | — | 1 | 5.62 |
| CHEMBL103600 | DIMETHYLNORDIHYDROGUARIERATE ACID | — | 1 | 5.51 |
| CHEMBL180947 | JASPIC ACID | — | 1 | 5.12 |
| CHEMBL465615 | HYRTENONE A | — | 1 | 4.41 |
| CHEMBL442427 | IGERNELLIN | — | 1 | - |
| CHEMBL455880 | HALENAQUINOL SULFATE SODIUM | — | 1 | - |
| CHEMBL230058 | HYDROHALISULFATE 1 | — | 1 | - |
| CHEMBL387584 | HALISULFATE 1 | — | 1 | - |
| CHEMBL457171 | SUBERSIC ACID | — | 1 | - |
| CHEMBL425166 | JASPAQUINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL463805 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL459185 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL463806 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL465616 | CHLOROPUUPEHENONE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL157844 | PUUPEHENONE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL103600 | DIMETHYLNORDIHYDROGUARIERATE ACID | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL180947 | JASPIC ACID | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL465615 | HYRTENONE A | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL442427 | IGERNELLIN | IC50 | - | — | - | |
| CHEMBL455880 | HALENAQUINOL SULFATE SODIUM | IC50 | > | 200000.0 | nM | - |
| CHEMBL230058 | HYDROHALISULFATE 1 | IC50 | - | — | - | |
| CHEMBL387584 | HALISULFATE 1 | IC50 | - | — | - | |
| CHEMBL457171 | SUBERSIC ACID | IC50 | - | — | - | |
| CHEMBL425166 | JASPAQUINOL | IC50 | - | — | - |