Assay Detail
Binding
CHEMBL987043
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HIV1 integrase strand transfer activity using immobilized DNA substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.50 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476564 | — | — | 1 | 7.85 |
| CHEMBL476357 | — | — | 1 | 7.70 |
| CHEMBL514836 | — | — | 1 | 7.62 |
| CHEMBL514555 | — | — | 1 | 7.58 |
| CHEMBL478239 | — | — | 1 | 7.48 |
| CHEMBL199145 | — | — | 1 | 7.48 |
| CHEMBL476565 | — | — | 1 | 7.40 |
| CHEMBL478452 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476564 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL476357 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL514836 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL514555 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL478239 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL199145 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL476565 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL478452 | — | IC50 | = | 123.0 | nM | 6.91 |