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Assay Detail

CHEMBL987060

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells after 144 hrs
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs.
Antonini I, Volpini R, Dal Ben D, Lambertucci C, Cristalli G.
Bioorg Med Chem (2008) 16 : 8440 -8446
PubMed 18774722 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.38 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL104423 1 8.15
CHEMBL86287 1 7.66
CHEMBL104900 1 7.36
CHEMBL505427 1 7.22
CHEMBL451910 1 7.00
CHEMBL521619 1 6.92
CHEMBL491412 1 6.85
CHEMBL523314 1 6.80
CHEMBL43482 MITONAFIDE 2.0 1 6.66
CHEMBL491411 1 6.11
CHEMBL521916 1 6.09
CHEMBL447697 1 6.07
CHEMBL522626 1 6.05
CHEMBL491807 1 6.03
CHEMBL9940 1 6.00
CHEMBL490796 1 5.85
CHEMBL453465 1 5.77
CHEMBL125475 1 5.77
CHEMBL489371 1 5.68
CHEMBL83297 1 5.17
CHEMBL522138 1 4.78
CHEMBL520528 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL104423 IC50 = 7.0 nM 8.15
CHEMBL86287 IC50 = 22.0 nM 7.66
CHEMBL104900 IC50 = 44.0 nM 7.36
CHEMBL505427 IC50 = 60.0 nM 7.22
CHEMBL451910 IC50 = 100.0 nM 7.00
CHEMBL521619 IC50 = 120.0 nM 6.92
CHEMBL491412 IC50 = 140.0 nM 6.85
CHEMBL523314 IC50 = 160.0 nM 6.80
CHEMBL43482 MITONAFIDE IC50 = 220.0 nM 6.66
CHEMBL491411 IC50 = 770.0 nM 6.11
CHEMBL521916 IC50 = 810.0 nM 6.09
CHEMBL447697 IC50 = 860.0 nM 6.07
CHEMBL522626 IC50 = 890.0 nM 6.05
CHEMBL491807 IC50 = 930.0 nM 6.03
CHEMBL9940 IC50 = 990.0 nM 6.00
CHEMBL490796 IC50 = 1400.0 nM 5.85
CHEMBL453465 IC50 = 1700.0 nM 5.77
CHEMBL125475 IC50 = 1700.0 nM 5.77
CHEMBL489371 IC50 = 2100.0 nM 5.68
CHEMBL83297 IC50 = 6700.0 nM 5.17
CHEMBL522138 IC50 = 16800.0 nM 4.78
CHEMBL520528 IC50 - -