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Assay Detail

CHEMBL987423

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CaCO2 cells after 24 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Caco-2
Confidence 1 — Organism
Curated By Autocuration

Target

Caco-2 (CHEMBL614058)
Type CELL-LINE
Organism Homo sapiens

Publication

Gallic acid-based indanone derivatives as anticancer agents.
Saxena HO, Faridi U, Srivastava S, Kumar JK, Darokar MP, Luqman S, Chanotiya CS, Krishna V, Negi AS, Khanuja SP.
Bioorg Med Chem Lett (2008) 18 : 3914 -3918
PubMed 18586491 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.57 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 8.70
CHEMBL428647 PACLITAXEL 4.0 1 8.10
CHEMBL518306 1 5.19
CHEMBL480139 1 4.30
CHEMBL480509 1 -
CHEMBL519428 1 -
CHEMBL518159 1 -
CHEMBL479950 1 -
CHEMBL479949 1 -
CHEMBL479761 1 -
CHEMBL446818 1 -
CHEMBL480508 1 -
CHEMBL480320 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 2.0 nM 8.70
CHEMBL428647 PACLITAXEL IC50 = 8.0 nM 8.10
CHEMBL518306 IC50 = 6400.0 nM 5.19
CHEMBL480139 IC50 = 49600.0 nM 4.30
CHEMBL480509 IC50 >= 250000.0 nM -
CHEMBL519428 IC50 = 115300.0 nM -
CHEMBL518159 IC50 = 112500.0 nM -
CHEMBL479950 IC50 >= 250000.0 nM -
CHEMBL479949 IC50 = 139600.0 nM -
CHEMBL479761 IC50 = 226000.0 nM -
CHEMBL446818 IC50 >= 250000.0 nM -
CHEMBL480508 IC50 = 206000.0 nM -
CHEMBL480320 IC50 >= 250000.0 nM -