Assay Detail
Binding
CHEMBL987565
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Inhibition of tubulin polymerization in rat C6 cells after 4 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cell-based screen for identification of inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.90 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.00 |
| CHEMBL89138 | CURACIN A | — | 1 | 6.29 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 5.21 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 5.09 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL89138 | CURACIN A | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL90555 | VINCRISTINE | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL159 | VINBLASTINE | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL44657 | ETOPOSIDE | EC50 | = | 680000.0 | nM | - |