Assay Detail

CHEMBL987713

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Binding

Inhibition of 5-alpha-reductase in rat liver microsome assessed as conversion of [14C] testosterone to [14C] dihydrotestosterone

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Tissue	Liver
Subcellular	Microsome
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.

Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R.
Bioorg Med Chem Lett (2009) 19 : 2154 -2157
PubMed 19289282 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	5.56	6.14
Activity	1	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL710	FINASTERIDE	4.0	1	6.14
CHEMBL1099224	GANODERIC ACID DM	—	2	4.97
CHEMBL8739	LINOLENIC ACID	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL710	FINASTERIDE	IC50	=	730.0	nM	6.14
CHEMBL1099224	GANODERIC ACID DM	IC50	=	10600.0	nM	4.97
CHEMBL1099224	GANODERIC ACID DM	Activity		-	—	-
CHEMBL8739	LINOLENIC ACID	IC50	=	116000.0	nM	-