Assay Detail
Binding
CHEMBL987974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DA reuptake at human dopamine transporter expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510484 | — | — | 1 | 5.05 |
| CHEMBL479410 | — | — | 1 | 4.96 |
| CHEMBL523146 | — | — | 1 | - |
| CHEMBL491408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510484 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL479410 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL523146 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL491408 | — | IC50 | > | 10000.0 | nM | - |