Assay Detail
Functional
CHEMBL987992
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Cytotoxicity against human A549 cells assessed as reduction of cell growth by SRB method
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.43 | 7.52 |
| Activity | 13 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 7.52 |
| CHEMBL502958 | — | — | 1 | 7.40 |
| CHEMBL475942 | — | — | 1 | 6.96 |
| CHEMBL477592 | — | — | 1 | 5.77 |
| CHEMBL477591 | — | — | 1 | 5.15 |
| CHEMBL478869 | — | — | 1 | 5.11 |
| CHEMBL478868 | — | — | 1 | 5.04 |
| CHEMBL475921 | — | — | 1 | 5.04 |
| CHEMBL478867 | — | — | 1 | 5.02 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.00 |
| CHEMBL478249 | — | — | 1 | 4.72 |
| CHEMBL475922 | — | — | 1 | 4.71 |
| CHEMBL478886 | — | — | 1 | 4.70 |
| CHEMBL509809 | — | — | 1 | 4.67 |
| CHEMBL447624 | — | — | 1 | 4.66 |
| CHEMBL517983 | — | — | 1 | - |
| CHEMBL517051 | — | — | 1 | - |
| CHEMBL518742 | — | — | 1 | - |
| CHEMBL477193 | — | — | 1 | - |
| CHEMBL515475 | — | — | 1 | - |
| CHEMBL479060 | — | — | 1 | - |
| CHEMBL449679 | — | — | 1 | - |
| CHEMBL477194 | — | — | 1 | - |
| CHEMBL475678 | — | — | 1 | - |
| CHEMBL514857 | — | — | 1 | - |
| CHEMBL516581 | — | — | 1 | - |
| CHEMBL478888 | — | — | 1 | - |
| CHEMBL478887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL502958 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL475942 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL477592 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL477591 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL478869 | — | IC50 | = | 7760.0 | nM | 5.11 |
| CHEMBL478868 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL475921 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL478867 | — | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL478249 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL475922 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL478886 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL509809 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL447624 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL517983 | — | Activity | - | — | - | |
| CHEMBL517051 | — | Activity | - | — | - | |
| CHEMBL518742 | — | Activity | - | — | - | |
| CHEMBL477193 | — | Activity | - | — | - | |
| CHEMBL515475 | — | Activity | - | — | - | |
| CHEMBL479060 | — | Activity | - | — | - | |
| CHEMBL449679 | — | Activity | - | — | - | |
| CHEMBL477194 | — | Activity | - | — | - | |
| CHEMBL475678 | — | Activity | - | — | - | |
| CHEMBL514857 | — | Activity | - | — | - | |
| CHEMBL516581 | — | Activity | - | — | - | |
| CHEMBL478888 | — | Activity | - | — | - | |
| CHEMBL478887 | — | Activity | - | — | - |