Assay Detail
Functional
CHEMBL987993
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Cytotoxicity against human KB cells assessed as reduction of cell growth by SRB method
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.38 | 8.40 |
| Activity | 12 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 8.40 |
| CHEMBL502958 | — | — | 1 | 7.40 |
| CHEMBL475942 | — | — | 1 | 6.39 |
| CHEMBL477592 | — | — | 1 | 5.49 |
| CHEMBL477591 | — | — | 1 | 5.21 |
| CHEMBL475921 | — | — | 1 | 5.04 |
| CHEMBL478249 | — | — | 1 | 4.95 |
| CHEMBL478867 | — | — | 1 | 4.92 |
| CHEMBL478869 | — | — | 1 | 4.92 |
| CHEMBL475922 | — | — | 1 | 4.89 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.85 |
| CHEMBL477194 | — | — | 1 | 4.84 |
| CHEMBL478886 | — | — | 1 | 4.80 |
| CHEMBL478868 | — | — | 1 | 4.79 |
| CHEMBL509809 | — | — | 1 | 4.74 |
| CHEMBL477193 | — | — | 1 | 4.49 |
| CHEMBL514857 | — | — | 1 | - |
| CHEMBL475678 | — | — | 1 | - |
| CHEMBL516581 | — | — | 1 | - |
| CHEMBL449679 | — | — | 1 | - |
| CHEMBL478887 | — | — | 1 | - |
| CHEMBL479060 | — | — | 1 | - |
| CHEMBL515475 | — | — | 1 | - |
| CHEMBL447624 | — | — | 1 | - |
| CHEMBL518742 | — | — | 1 | - |
| CHEMBL517051 | — | — | 1 | - |
| CHEMBL517983 | — | — | 1 | - |
| CHEMBL478888 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL502958 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL475942 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL477592 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL477591 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL475921 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL478249 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL478867 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL478869 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL475922 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL477194 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL478886 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL478868 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL509809 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL477193 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL514857 | — | Activity | - | — | - | |
| CHEMBL475678 | — | Activity | - | — | - | |
| CHEMBL516581 | — | Activity | - | — | - | |
| CHEMBL449679 | — | Activity | - | — | - | |
| CHEMBL478887 | — | Activity | - | — | - | |
| CHEMBL479060 | — | Activity | - | — | - | |
| CHEMBL515475 | — | Activity | - | — | - | |
| CHEMBL447624 | — | Activity | - | — | - | |
| CHEMBL518742 | — | Activity | - | — | - | |
| CHEMBL517051 | — | Activity | - | — | - | |
| CHEMBL517983 | — | Activity | - | — | - | |
| CHEMBL478888 | — | Activity | - | — | - |