Assay Detail
Binding
CHEMBL988355
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Inhibition of DPP8
41
Total Activities
41
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.54 | 6.83 |
| Activity | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505629 | — | — | 1 | 6.83 |
| CHEMBL481177 | — | — | 1 | 6.44 |
| CHEMBL481669 | — | — | 1 | 6.40 |
| CHEMBL480914 | — | — | 1 | 6.30 |
| CHEMBL479381 | — | — | 1 | 6.20 |
| CHEMBL481288 | — | — | 1 | 6.19 |
| CHEMBL511125 | — | — | 1 | 6.08 |
| CHEMBL479736 | — | — | 1 | 5.78 |
| CHEMBL520434 | — | — | 1 | 5.78 |
| CHEMBL520921 | — | — | 1 | 5.69 |
| CHEMBL480154 | — | — | 1 | 5.68 |
| CHEMBL480155 | — | — | 1 | 5.67 |
| CHEMBL519265 | — | — | 1 | 5.66 |
| CHEMBL479380 | — | — | 1 | 5.66 |
| CHEMBL471960 | — | — | 1 | 5.62 |
| CHEMBL471956 | — | — | 1 | 5.62 |
| CHEMBL481290 | — | — | 1 | 5.52 |
| CHEMBL479567 | — | — | 1 | 5.52 |
| CHEMBL479803 | — | — | 1 | 5.51 |
| CHEMBL480942 | — | — | 1 | 5.49 |
| CHEMBL480705 | — | — | 1 | 5.47 |
| CHEMBL482261 | — | — | 1 | 5.39 |
| CHEMBL520266 | — | — | 1 | 5.19 |
| CHEMBL482104 | — | — | 1 | 5.14 |
| CHEMBL480712 | — | — | 1 | 5.00 |
| CHEMBL482262 | — | — | 1 | 4.96 |
| CHEMBL479983 | — | — | 1 | 4.94 |
| CHEMBL480537 | — | — | 1 | 4.88 |
| CHEMBL480536 | — | — | 1 | 4.83 |
| CHEMBL452998 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505629 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL481177 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL481669 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL480914 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL479381 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL481288 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL511125 | — | IC50 | = | 837.0 | nM | 6.08 |
| CHEMBL479736 | — | IC50 | = | 1667.0 | nM | 5.78 |
| CHEMBL520434 | — | IC50 | = | 1675.0 | nM | 5.78 |
| CHEMBL520921 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL480154 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL480155 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL519265 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL479380 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL471956 | — | IC50 | = | 2375.0 | nM | 5.62 |
| CHEMBL471960 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL481290 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL479567 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL479803 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL480942 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL480705 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL482261 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL520266 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL482104 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL480712 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL482262 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL479983 | — | IC50 | = | 11499.0 | nM | 4.94 |
| CHEMBL480537 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL480536 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL452998 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL480781 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL480324 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL480713 | — | Activity | - | — | - | |
| CHEMBL480943 | — | Activity | - | — | - | |
| CHEMBL519272 | — | Activity | - | — | - | |
| CHEMBL480913 | — | Activity | - | — | - | |
| CHEMBL509391 | — | Activity | - | — | - | |
| CHEMBL471784 | — | Activity | - | — | - | |
| CHEMBL471785 | — | Activity | - | — | - | |
| CHEMBL479538 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL479794 | — | IC50 | > | 10000.0 | nM | - |