Assay Detail
Binding
CHEMBL988583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 4 (CHEMBL6126) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.52 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504955 | — | — | 1 | 6.62 |
| CHEMBL118987 | — | — | 1 | 6.50 |
| CHEMBL490470 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504955 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL118987 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL490470 | — | EC50 | = | 360.0 | nM | 6.44 |