Assay Detail

CHEMBL988883

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Binding

Inhibition of Cyclin D3/CDK6

ChEMBL ↗

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Target

G1/S-specific cyclin-D3 (CHEMBL2422) ↗

Open DB target context

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G1/S-specific cyclin-D3 (CHEMBL2422) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target G1/S-specific cyclin-D3

CHEMBL2422

Anchored from Assay target.

Protein identity G1/S-specific cyclin-D3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

G1/S-specific cyclin-D3 (CHEMBL2422) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.

Anderson M, Andrews DM, Barker AJ, Brassington CA, Breed J, Byth KF, Culshaw JD, Finlay MR, Fisher E, McMiken HH, Green CP, Heaton DW, Nash IA, Newcombe NJ, Oakes SE, Pauptit RA, Roberts A, Stanway JJ, Thomas AP, Tucker JA, Walker M, Weir HM.
Bioorg Med Chem Lett (2008) 18 : 5487 -5492
PubMed 18815031 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.68	7.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL488436	AZD-5438	1.0	1	7.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL488436	AZD-5438	IC50	=	21.0	nM	7.68