Assay Detail
Binding
CHEMBL989026
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Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.62 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25230 | — | — | 1 | 9.49 |
| CHEMBL494479 | — | — | 1 | 9.37 |
| CHEMBL494480 | ADL-5859 | 2.0 | 1 | 9.08 |
| CHEMBL13470 | SNC-80 | — | 1 | 8.92 |
| CHEMBL495094 | — | — | 1 | 8.82 |
| CHEMBL494462 | — | — | 1 | 8.74 |
| CHEMBL494275 | — | — | 1 | 8.46 |
| CHEMBL494265 | — | — | 1 | 8.03 |
| CHEMBL494266 | — | — | 1 | 7.96 |
| CHEMBL495278 | — | — | 1 | 7.75 |
| CHEMBL495073 | — | — | 1 | 7.24 |
| CHEMBL495074 | — | — | 1 | 7.23 |
| CHEMBL494472 | — | — | 1 | 7.17 |
| CHEMBL492447 | — | — | 1 | 7.15 |
| CHEMBL492448 | — | — | 1 | 7.14 |
| CHEMBL492449 | — | — | 1 | 6.82 |
| CHEMBL493687 | — | — | 1 | 6.80 |
| CHEMBL523204 | — | — | 1 | 6.48 |
| CHEMBL523507 | — | — | 1 | 6.44 |
| CHEMBL493454 | — | — | 1 | 6.32 |
| CHEMBL522004 | — | — | 1 | 6.30 |
| CHEMBL494274 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25230 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL494479 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL494480 | ADL-5859 | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL13470 | SNC-80 | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL495094 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL494462 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL494275 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL494265 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL494266 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL495278 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL495073 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL495074 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL494472 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL492447 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL492448 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL492449 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL493687 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL523204 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL523507 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL493454 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL522004 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL494274 | — | Ki | = | 1300.0 | nM | 5.89 |