Assay Detail
Functional
CHEMBL989028
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Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS binding
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.28 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25230 | — | — | 1 | 9.40 |
| CHEMBL494479 | — | — | 1 | 8.85 |
| CHEMBL13470 | SNC-80 | — | 1 | 8.00 |
| CHEMBL494462 | — | — | 1 | 7.72 |
| CHEMBL494480 | ADL-5859 | 2.0 | 1 | 7.70 |
| CHEMBL494265 | — | — | 1 | 7.09 |
| CHEMBL494275 | — | — | 1 | 7.05 |
| CHEMBL495094 | — | — | 1 | 6.85 |
| CHEMBL495073 | — | — | 1 | 6.72 |
| CHEMBL495278 | — | — | 1 | 6.70 |
| CHEMBL495074 | — | — | 1 | 6.66 |
| CHEMBL494266 | — | — | 1 | 6.66 |
| CHEMBL492447 | — | — | 1 | 6.42 |
| CHEMBL492448 | — | — | 1 | 6.09 |
| CHEMBL523204 | — | — | 1 | - |
| CHEMBL493454 | — | — | 1 | - |
| CHEMBL494274 | — | — | 1 | - |
| CHEMBL494472 | — | — | 1 | - |
| CHEMBL492449 | — | — | 1 | - |
| CHEMBL523507 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25230 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL494479 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL13470 | SNC-80 | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL494462 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL494480 | ADL-5859 | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL494265 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL494275 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL495094 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL495073 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL495278 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL495074 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL494266 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL492447 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL492448 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL523204 | — | EC50 | - | — | - | |
| CHEMBL493454 | — | EC50 | - | — | - | |
| CHEMBL494274 | — | EC50 | - | — | - | |
| CHEMBL494472 | — | EC50 | - | — | - | |
| CHEMBL492449 | — | EC50 | - | — | - | |
| CHEMBL523507 | — | EC50 | - | — | - |