Assay Detail
Binding
CHEMBL989030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG channel in HEK293 cells by voltage-clamp method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.52 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523204 | — | — | 1 | 6.52 |
| CHEMBL492449 | — | — | 1 | 6.42 |
| CHEMBL492448 | — | — | 1 | 6.33 |
| CHEMBL495073 | — | — | 1 | 6.23 |
| CHEMBL495074 | — | — | 1 | 6.19 |
| CHEMBL494265 | — | — | 1 | 6.18 |
| CHEMBL492447 | — | — | 1 | 6.17 |
| CHEMBL494275 | — | — | 1 | 6.12 |
| CHEMBL494472 | — | — | 1 | 5.74 |
| CHEMBL493454 | — | — | 1 | 5.19 |
| CHEMBL494462 | — | — | 1 | 5.10 |
| CHEMBL523507 | — | — | 1 | 4.74 |
| CHEMBL494479 | — | — | 1 | 4.70 |
| CHEMBL494274 | — | — | 1 | 4.32 |
| CHEMBL495094 | — | — | 1 | 4.22 |
| CHEMBL494480 | ADL-5859 | 2.0 | 1 | 4.11 |
| CHEMBL494266 | — | — | 1 | - |
| CHEMBL495278 | — | — | 1 | - |
| CHEMBL25230 | — | — | 1 | - |
| CHEMBL13470 | SNC-80 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523204 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL492449 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL492448 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL495073 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL495074 | — | IC50 | = | 643.0 | nM | 6.19 |
| CHEMBL494265 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL492447 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL494275 | — | IC50 | = | 766.0 | nM | 6.12 |
| CHEMBL494472 | — | IC50 | = | 1814.0 | nM | 5.74 |
| CHEMBL493454 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL494462 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL523507 | — | IC50 | = | 18310.0 | nM | 4.74 |
| CHEMBL494479 | — | IC50 | = | 19750.0 | nM | 4.70 |
| CHEMBL494274 | — | IC50 | = | 47440.0 | nM | 4.32 |
| CHEMBL495094 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL494480 | ADL-5859 | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL494266 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL495278 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL25230 | — | IC50 | - | — | - | |
| CHEMBL13470 | SNC-80 | IC50 | - | — | - |