Assay Detail
Binding
CHEMBL989245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hamster liver ALDH2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetinae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.76 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114083 | — | — | 1 | 7.40 |
| CHEMBL113123 | — | — | 1 | 7.40 |
| CHEMBL114397 | — | — | 1 | 7.40 |
| CHEMBL112696 | — | — | 1 | 7.30 |
| CHEMBL486422 | DAIDZIN | — | 1 | 7.10 |
| CHEMBL115092 | — | — | 1 | 7.10 |
| CHEMBL113586 | — | — | 1 | 7.00 |
| CHEMBL262662 | — | — | 1 | 6.89 |
| CHEMBL419936 | — | — | 1 | 5.92 |
| CHEMBL110472 | — | — | 1 | 5.82 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 5.05 |
| CHEMBL113616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114083 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL113123 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL114397 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL112696 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL486422 | DAIDZIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL115092 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL113586 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL262662 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL419936 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL110472 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL113616 | — | IC50 | > | 9000.0 | nM | - |