Assay Detail

CHEMBL989307

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Functional

Antagonist activity at 5-HT receptor in Sprague-Dawley rat endothelium denuded thoracic aorta assessed as inhibition of 5HT-induced contraction

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Thoracic aorta
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.

Chiou WF, Liao JF, Chen CF.
J Nat Prod (1996) 59 : 374 -378
PubMed 8699182 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	6.25	6.25

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL486598	EVODIAMINE	—	1	6.25

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL486598	EVODIAMINE	Kd	=	562.34	nM	6.25