Assay Detail
Binding
CHEMBL989312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig lens aldose reductase by spectrophotometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL4559) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.73 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463755 | — | — | 1 | 5.75 |
| CHEMBL458251 | — | — | 1 | 5.30 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | 4.80 |
| CHEMBL457815 | — | — | 1 | 4.52 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.30 |
| CHEMBL463753 | — | — | 1 | 4.29 |
| CHEMBL471479 | PERSICARIN | — | 1 | 4.16 |
| CHEMBL379064 | ISORHAMNETIN | — | 1 | - |
| CHEMBL457148 | RHAMNAZIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463755 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL458251 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL250450 | ISOQUERCETIN | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL457815 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL50 | QUERCETIN | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL463753 | — | IC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL471479 | PERSICARIN | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL379064 | ISORHAMNETIN | IC50 | > | 95000.0 | nM | - |
| CHEMBL457148 | RHAMNAZIN | IC50 | > | 91000.0 | nM | - |