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Assay Detail

CHEMBL989581

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Binding
Inhibition of COX2 by enzyme immunoassay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives.
Wuest F, Tang X, Kniess T, Pietzsch J, Suresh M.
Bioorg Med Chem (2009) 17 : 1146 -1151
PubMed 19157881 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.83 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL108201 1 8.15
CHEMBL457332 1 7.52
CHEMBL455837 1 7.40
CHEMBL118 CELECOXIB 4.0 1 7.16
CHEMBL458647 1 6.96
CHEMBL512917 1 6.92
CHEMBL449930 1 6.82
CHEMBL514418 1 6.77
CHEMBL452660 1 6.72
CHEMBL507789 1 6.68
CHEMBL457331 1 6.44
CHEMBL458026 1 5.60
CHEMBL458025 1 5.60
CHEMBL512916 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL108201 IC50 = 7.0 nM 8.15
CHEMBL457332 IC50 = 30.0 nM 7.52
CHEMBL455837 IC50 = 40.0 nM 7.40
CHEMBL118 CELECOXIB IC50 = 70.0 nM 7.16
CHEMBL458647 IC50 = 110.0 nM 6.96
CHEMBL512917 IC50 = 120.0 nM 6.92
CHEMBL449930 IC50 = 150.0 nM 6.82
CHEMBL514418 IC50 = 170.0 nM 6.77
CHEMBL452660 IC50 = 190.0 nM 6.72
CHEMBL507789 IC50 = 210.0 nM 6.68
CHEMBL457331 IC50 = 360.0 nM 6.44
CHEMBL458026 IC50 = 2500.0 nM 5.60
CHEMBL458025 IC50 = 2500.0 nM 5.60
CHEMBL512916 IC50 > 10000.0 nM -