Assay Detail
Binding
CHEMBL989588
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Inhibition of human adrenergic alpha2A receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477650 | — | — | 1 | 6.16 |
| CHEMBL475969 | — | — | 1 | 5.96 |
| CHEMBL457570 | — | — | 1 | - |
| CHEMBL515307 | — | — | 1 | - |
| CHEMBL476006 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477650 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL475969 | — | IC50 | = | 1097.0 | nM | 5.96 |
| CHEMBL457570 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL515307 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL476006 | — | IC50 | > | 1000.0 | nM | - |