Assay Detail
Binding
CHEMBL989632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.83 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505194 | — | — | 1 | 7.42 |
| CHEMBL498866 | — | — | 1 | 7.30 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 7.28 |
| CHEMBL467592 | — | — | 1 | 7.22 |
| CHEMBL467593 | — | — | 1 | 7.16 |
| CHEMBL513873 | — | — | 1 | 7.16 |
| CHEMBL464131 | — | — | 1 | 7.00 |
| CHEMBL464341 | — | — | 1 | 6.85 |
| CHEMBL468760 | — | — | 1 | 6.82 |
| CHEMBL494817 | — | — | 1 | 6.70 |
| CHEMBL510554 | — | — | 1 | 6.51 |
| CHEMBL511065 | — | — | 1 | 6.50 |
| CHEMBL504620 | — | — | 1 | 6.43 |
| CHEMBL507524 | — | — | 1 | 6.30 |
| CHEMBL492795 | — | — | 1 | 6.29 |
| CHEMBL506893 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505194 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL498866 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL467592 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL467593 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL513873 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL464131 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL464341 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL468760 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL494817 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL510554 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL511065 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL504620 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL507524 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL492795 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL506893 | — | IC50 | = | 530.0 | nM | 6.28 |