Assay Detail
Functional
CHEMBL989633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phenylephrine-induced contraction of smooth muscles in New Zealand white rabbit corpus cavernosum
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Corpus cavernosum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.26 | 7.08 |
| Emax | 20 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467593 | — | — | 2 | 7.08 |
| CHEMBL510226 | — | — | 2 | 6.86 |
| CHEMBL468571 | — | — | 2 | 6.83 |
| CHEMBL192 | SILDENAFIL | 4.0 | 2 | 6.77 |
| CHEMBL468760 | — | — | 2 | 6.62 |
| CHEMBL513873 | — | — | 2 | 6.57 |
| CHEMBL467592 | — | — | 2 | 6.52 |
| CHEMBL511065 | — | — | 2 | 6.36 |
| CHEMBL494817 | — | — | 2 | 6.26 |
| CHEMBL498866 | — | — | 2 | 6.25 |
| CHEMBL468572 | — | — | 2 | 6.16 |
| CHEMBL464341 | — | — | 2 | 6.14 |
| CHEMBL506893 | — | — | 2 | 6.14 |
| CHEMBL492795 | — | — | 2 | 6.11 |
| CHEMBL449906 | — | — | 2 | 6.06 |
| CHEMBL510554 | — | — | 2 | 5.79 |
| CHEMBL507524 | — | — | 2 | 5.73 |
| CHEMBL505194 | — | — | 2 | 5.72 |
| CHEMBL464131 | — | — | 2 | 5.68 |
| CHEMBL512979 | — | — | 2 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467593 | — | EC50 | = | 83.18 | nM | 7.08 |
| CHEMBL510226 | — | EC50 | = | 138.04 | nM | 6.86 |
| CHEMBL468571 | — | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL192 | SILDENAFIL | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL468760 | — | EC50 | = | 239.88 | nM | 6.62 |
| CHEMBL513873 | — | EC50 | = | 269.15 | nM | 6.57 |
| CHEMBL467592 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL511065 | — | EC50 | = | 436.52 | nM | 6.36 |
| CHEMBL494817 | — | EC50 | = | 549.54 | nM | 6.26 |
| CHEMBL498866 | — | EC50 | = | 562.34 | nM | 6.25 |
| CHEMBL468572 | — | EC50 | = | 691.83 | nM | 6.16 |
| CHEMBL506893 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL464341 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL492795 | — | EC50 | = | 776.25 | nM | 6.11 |
| CHEMBL449906 | — | EC50 | = | 870.96 | nM | 6.06 |
| CHEMBL510554 | — | EC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL507524 | — | EC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL505194 | — | EC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL464131 | — | EC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL512979 | — | EC50 | = | 2818.38 | nM | 5.55 |
| CHEMBL468571 | — | Emax | = | 113.0 | % | - |
| CHEMBL192 | SILDENAFIL | Emax | = | 105.0 | % | - |
| CHEMBL506893 | — | Emax | = | 123.0 | % | - |
| CHEMBL510226 | — | Emax | = | 108.0 | % | - |
| CHEMBL513873 | — | Emax | = | 105.0 | % | - |
| CHEMBL511065 | — | Emax | = | 100.0 | % | - |
| CHEMBL498866 | — | Emax | = | 112.0 | % | - |
| CHEMBL464341 | — | Emax | = | 97.0 | % | - |
| CHEMBL464131 | — | Emax | = | 75.0 | % | - |
| CHEMBL512979 | — | Emax | = | 100.0 | % | - |
| CHEMBL467593 | — | Emax | = | 105.0 | % | - |
| CHEMBL467592 | — | Emax | = | 119.0 | % | - |
| CHEMBL449906 | — | Emax | = | 96.0 | % | - |
| CHEMBL494817 | — | Emax | = | 69.0 | % | - |
| CHEMBL468760 | — | Emax | = | 119.0 | % | - |
| CHEMBL507524 | — | Emax | = | 61.0 | % | - |
| CHEMBL505194 | — | Emax | = | 60.0 | % | - |
| CHEMBL492795 | — | Emax | = | 51.0 | % | - |
| CHEMBL468572 | — | Emax | = | 119.0 | % | - |
| CHEMBL510554 | — | Emax | = | 68.0 | % | - |